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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Circ Cardiovasc Genet. 2012 Dec 19;6(1):10–18. doi: 10.1161/CIRCGENETICS.112.965277

Figure 1.

Figure 1

Chromosome 18 locus that includes FHOD3 is associated with HCM. A. Graph shows the − log(p-value) and the location of each SNP contained on the 370CNV array that is within the chromosome 18 locus identified by the HCM GWA study. The SNP with the strongest association with HCM is shown in blue. SNPs in LD with rs516514 are shown from red (strong LD) to yellow (weak LD). Relative sites of recombination are shown in blue lines. B. Quantitative real time PCR demonstrating expression of FHOD3 RNA in mouse tissues. The strongest expression was found in the heart. C. Alignment of FHOD3 peptide showing conservation of FHOD3-V1151 (red box) in mammals. Amino acids conserved across all species shown are marked by asterisk.