Spatial distribution of vBMD differences associated with aging. Anterior views of volumetric representations of voxel-wise vBMD differences between young (n=94) and middle-age (n=98) American women (A; 0-177 mg/cm3), young (n=94) and older (n=157) American women (B; 0-398 mg/cm3), and between young American (n=94) and older Icelandic control (n=148) women (C; 0-393 mg/cm3). Voxels were assigned transparency based on their difference values, from full transparency for zero vBMD differences, to full opacity for vBMD differences=398 mg/cm3. Mid-coronal cross-sections of the T-maps of the voxel-wise vBMD differences between young (n=94) and middle-age (n=98) American women (D; 2.1-9.5 T-values), and young (n=94) and older (n=157) American women (E; 2.0-19.3 T-values). Voxels were assigned transparency based on their T-values, from full transparency for non-significant voxels (T<2·1 in D; T<2·0 in E), to full opacity for T-values=19.3. FEM stance loading von Mises stress map (F) and principal strain map (G) of a representative control women. FEA = Finite Element Analysis.