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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Struct Biol. 2013 Jan 4;181(3):243–251. doi: 10.1016/j.jsb.2012.12.009

Table 2.

Thermodynamic parameters for the SHP-1/ JAK1AL peptide interaction measured by ITC.

SHP-1 JAK1 peptide Kd (μM) N Enthalpy ΔH (kcal/mol) Entropy TΔS (kcal/mol)
C453S pY Y 13.7 ± 1.4 0.7 −28.7 ± 7.3 −22.0
C453S Y pY 5.6 ± 1.1 0.9 −21.5 ± 3.5 −14.4
C453S pY pY 0.7 ± 0.1 0.8 −16.6 ± 0.5 −8.3
C453S/Q252A pY pY 0.6 ± 0.1 0.9 −16.6 ± 0.4 −8.1
C453S/Q252R pY pY 0.5 ± 0.1 0.9 −17.4 ± 0.4 −8.8

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