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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Immunol. 2013 Jan 21;190(5):2138–2149. doi: 10.4049/jimmunol.1202801

Figure 1.

Figure 1

Avirulent properties of p27 knockout L. donovani (Ldp27−/−) parasite in BALB/c mice. Survival of wild type (Wt) or Ldp27−/− parasites in Liver (A) and Spleen (B) of BALB/c mice. Mice were infected with Wt or Ldp27−/− parasites, and at 4, 8 and 16 weeks (ws) post-infection (PI) parasite load in infected mice was measured. (C) Effect of immunosuppressive drug Dexamethasone (DXM) on infected mice. Parasite load was measured in spleen of mice infected with Wt or p27−/− parasite for different weeks of post-infection and treated with DXM. (D) Histopathology of liver from Wt or Ldp27−/− infected mice after 6 weeks and 16 weeks post-infection. Black arrows pointing infection foci or intra-cellular parasites. The data presented are representative of three independent experiments with similar results and 4 mice in each group. Mean and SEM of each group are shown. *, p < 0.05.