Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Steady-state kinetic parameters for hpol ι26–446-catalyzed primer extension in the presence of MK886 as determined using a fluorescence-based assay.
| [MK886] (μM) | k cat | K M,dNTP | kcat/KM,dNTP | |
|---|---|---|---|---|
| (min−1) | (μM) | (min−1 μM−1) | Fold decrease in kcat/KM,dNTP | |
| 0 | 5.6 ± 0.1 | 0.8 ± 0.2 | 7.0 | - |
| 20 | 4.4 ± 0.1 | 1.0 ± 0.2 | 4.4 | 1.6 |
| 40 | 4.3 ± 0.1 | 1.3 ± 0.2 | 3.3 | 2.1 |
| 60 | 4.1 ± 0.2 | 1.4 ± 0.3 | 2.9 | 2.4 |
