Table 2.
Hemodynamic and arterial blood values.
| Control (n=6) | THX (n=6) | PAB (n=5) | PAB + THX (n=6) | |||||
|---|---|---|---|---|---|---|---|---|
| DAY 1 | DAY 7 | DAY 1 | DAY 7 | DAY 1 | DAY 7 | DAY 1 | DAY 7 | |
| Gestational age, days | 126 ± 1 | 133 ± 1 | 127 ± 1 | 134 ± 1 | 126 ± 1 | 133 ± 1 | 126 ± 1 | 133 ± 1 |
| Fetal weight, kg | 3.66 ± 0.25 | 3.36 ± 0.53 | 3.15 ± 0.35 | 3.82 ± 0.26 | ||||
| Heart weight/ Fetal weight, g/kg |
4.72 ± 0.12 | 4.95 ± 0.27 | 6.27 ± 0.85* | 4.94 ± 0.13 | ||||
| pH | 7.36 ± 0.01 | 7.31 ± 0.02 | 7.38 ± 0.02 | 7.36 ± 0.02 | 7.34 ± 0.02 | 7.36 ± 0.01 | 7.39 ± 0.11 | 7.36 ± 0.02 |
| PO2, torr | 22 ± 2 | 18 ± 2 | 19 ± 2 | 20 ± 1 | 19 ± 2 | 18 ± 2 | 19 ± 1 | 20 ± 2 |
| PCO2, torr | 51 ± 2 | 58 ± 7 | 50 ± 2 | 53 ± 2 | 52 ± 2 | 57 ± 2 | 52 ± 2 | 53 ± 3 |
| MABP, mmHg | 43 ± 2 | 43 ± 2 | 45 ± 2 | 39 ± 2 | 45 ± 2 | 46 ± 2 | 42 ± 2 | 42 ± 2 |
| HR, bpm | 163 ± 12 | 161 ± 10 | 151 ± 11 | 124 ± 8† | 178 ± 3 | 158 ± 6 | 150 ± 4 | 131 ± 5† |
| T4, ug/dL | 9.58 ± 1.02 | 8.00 ± 0.51 | 4.66 ± 0.44 | 0.12 ± 0.03† | 9.05 ± 0.93 | 7.50 ± 1.10 | 3.92 ± 0.36 | 0.21 ± 0.02† |
Values are means ± SE. n = number of animals in each group; Heart weight = RV + LV + septum weight; T4, thyroxine;
*
p < 0.05 compared to all other groups;
†
p < 0.05 compared to same group Day 1 values and Day 7 control and PAB values.