Table 2.

Current subject characteristics by superior cavopulmonary connection status.

	Superior cavopulmonary connection, mean ± standard deviation or % (n)	No superior cavopulmonary connection, mean ± standard deviation or % (n)	Adjusted p-value*
Post-Fontan medical history
Total number of subjects	408	138
Weight for age at study (percentile)	38 ± 32	48 ± 31	0.05
Height for age at study (percentile)	33 ± 31	36 ± 28	0.1
Number of surgeries	0.4 ± 0.9	0.5 ± 1.1	0.05
Stroke (%)	2	1	0.02
Thrombosis (%)	6	11	0.01
Protein-losing enteropathy (%)	4	4	0.4
Arrhythmia (%)	18	28	0.5
Child Health Questionnaire Physical Summary Score	45 ± 12 (n = 380)	45 ± 11 (n = 131)	0.3
Child Health Questionnaire Psychosocial Summary Score	47 ± 11 (n = 380)	49 ± 10 (n = 131)	0.01
Echocardiography
Ejection fraction (%)	59 ± 11 (n = 318)	58 ± 10 (n = 96)	0.3
Mass to volume ratio z-score	1.2 ± 0.4 (n = 314)	1.2 ± 0.4 (n = 92)	0.3
Exercise testing
Resting oxygen saturation (%)	94 ± 4 (n = 291)	94 ± 4 (n = 114)	0.07
Peak oxygen consumption (ml/kg/min)	27 ± 6 (n = 109)	27 ± 6 (n = 57)	0.2
Per cent predicted peak oxygen consumption	67 ± 15 (n = 109)	66 ± 14 (n = 57)	0.2
Peak oxygen consumption at ventilatory anaerobic threshold (ml/kg/min)	18 ± 6 (n = 105)	18 ± 5 (n = 57)	0.6
Per cent predicted peak oxygen consumption at ventilatory anaerobic threshold	78 ± 23 (n = 105)	75 ± 19 (n = 57)	0.9
Brain natriuretic peptide (pg/ml), mean	23 ± 46 (n = 377)	34 ± 53 (n = 133)	0.7
Brain natriuretic peptide (pg/ml), median (IQR)	12 (7–23)	18 (8–36)

IQR5interquartile range

^*p-value adjusted for centre, age at enrolment, year of Fontan, age at Fontan