Table I.

Characterization of B cells in tissues from humans and hu-mice

Analysis of protein expression was performed by flow cytometry on gated human (Hu.) and humouse (Hu-mo.) B cells defined as hCD45⁺ and CD19⁺ and/or CD20⁺. In the bone marrow (BM) of hu-mice, analysis was also performed on the developmental early fraction of CD19⁺CD20⁻ B cells. Analysis of spleen B cells from hu-mice is separated for mice of categories I–II and III–V. The relative protein expression level (a) or frequency of positive cells (b) is depicted in a grayscale format and with + and − symbols, with black and ++++ representing the highest expression (a) or frequency (b). ND = not determined.