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. Author manuscript; available in PMC: 2013 Feb 21.
Published in final edited form as: Nature. 2009 Aug 9;460(7259):1136–1139. doi: 10.1038/nature08290

Figure 1. Functional reprogramming of the Ink4/Arf locus.

Figure 1

a. Expression of the indicated genes in iPS compared with their parental MEFs and with ES cells measured by quantitative RT-PCR. b. Epigenetic marks present at the indicated promoters. Sequential ChIP, first of H3K27me3 and then of H3K4me3, is in the leftmost panel. Data correspond to the average ± s.d. of a representative assay from at least 2 independent assays. c. Expression of the indicated genes in iPS and in ES cells undergoing differentiation by addition of retinoic acid in the absence of LIF. Data correspond to the average ± s.d. of at least 2 independent assays. d. Re-expression of Arf in a teratoma developed in a chimeric-iPS mouse detected by immunohistochemistry.