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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Pain. 2012 Aug 31;153(11):2283–2291. doi: 10.1016/j.pain.2012.07.037

Fig. 4.

Fig. 4

(A) Role of inflammatory cytokines in complete Freund’s adjuvant (CFA)-induced upregulation of CB1R mRNA in intact trigeminal ganglia (TG) of male rats. CFA-induced changes in CB1R mRNA levels were assessed in intact TG of male rats treated with interleukin (IL)-1 receptor antagonist (IL-1RA), IL-6 inhibitor, gp130, and vehicle. Data are normalized to that of TG obtained from naïve rats. Each group consisted of 6 rats. (B) Effects of arachidonylcyclopropylamide (ACPA) on CFA-induced masseter hypersensitivity were assessed under the same experimental conditions as in A. Each group consisted of 6–8 rats. (C) CB1R mRNA in intact TG from male rats treated with direct masseteric injections of IL-1β, IL-6 with its receptor (IL-6R), and vehicle control. Data are normalized to that of naïve male rats and each group consisted of 6 rats *denotes significant group effects at P < 0.05. PBS, phosphate-buffered saline.