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. 2012 Oct 19;22(5):772–780. doi: 10.1089/scd.2012.0266

FIG. 6.

FIG. 6.

Effect of IGF-1R silencing on proliferation of damaged mouse PTEC. PTEC were exposed to IGF-1 and exosomes derived from hBM-MSC treated with scramble siRNA (hExo-siScramble) or siRNA specific for IGF-1R (hExo-siIGF-1R). PTEC were exposed to medium or cisplatin 2.5 μM for 6h, and then incubated with test medium or with IGF-1 and hExo preparations. PTEC proliferation was estimated after 4 days by cell count using trypan blue dye exclusion and PTEC+cispl was taken as 100%. Results are expressed as mean±S.E (n=4). Analysis of variance with Bonferroni correction was performed; *P<0.05 versus PTEC+cispl, °P<0.05 versus PTEC+cispl+IGF-1+hExo-siScramble.