Figure 2. Relationship between Lewy pathology burden and disease state by Braak PD stage.
Lewy pathology burden scores (LP total) were derived by summating semiquantitative scores from 16 foci throughout the brain (table e-1). Median LP total scores were compared between normal (0), incidental Lewy body disease (ILBD) with Braak Parkinson disease (PD) stages 1 and 2 (I 1-2), 3 and 4 (I 3-4), and 5 and 6 (I 5-6), as well as PD with Braak PD 3 (PD3) and 5 and 6 (PD5-6). Note that median LP total in ILBD with Braak PD stages 5 and 6 was significantly lower than that in PD with Braak PD stages 5 and 6. The circles represent normal subjects, the triangles ILBD, and the squares PD. Horizontal bars indicate median values.