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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Clin Cancer Res. 2012 Mar 8;18(8):2199–2209. doi: 10.1158/1078-0432.CCR-11-1669

Figure 5. IL13Rα2-specific CTLs ablate the tumor initiation population of IL13Rα2-expressing GSCs.

Figure 5

(A) PBT017-4 TS (2×105) were co-injected i.c. with the specified CTL (2×106) or PBS into NOD-scid mice; n = 6 mice per group. Mice were euthanized after 8 weeks, and harvested brains were analyzed by IHC for tumor engraftment using anti-human nestin (number of mice with engrafted tumors per group of 6 is indicated). Representative images from 2 mice per group are depicted (tiled horizontal brain sections). (B) U87 cells (2×105), and (C) PBT003-4 TS cells (2×105) were co-injected i.c. with CAR+ CTLs or PBS in NOD-scid mice as described in (A)