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. Author manuscript; available in PMC: 2013 Jul 20.
Published in final edited form as: J Mol Biol. 2012 May 1;420(4-5):384–399. doi: 10.1016/j.jmb.2012.04.025

Fig. 7.

Fig. 7

A hidden correlation between positions 11 and 20. (a) The crystal structures of S.c. TIM and T. maritima TIM [Protein Data Bank entries 1YPI (pink) and 1B9B (green)] are aligned and residues 11 and 20 are highlighted. The F11W mutation may have introduced a steric clash resulting in destabilization. (b) CD thermal denaturation of F11W and F11W I20A. I20A alone did not express in appreciable quantities.