Table 1.

Risk loci for Parkinson’s disease, indicating location, minor allele frequency (MAF) and odds ratio (OR), primarily calculated under an additive model. Included are references to papers that initially implicated these loci, and those that proved association (based on genome wide significance).

Chromosome	Gene Names*	MAF	OR	Initially Implicated	Genome Wide Significance**
1q21	GBA	0.01	5.43	Neudorfer et al48	Sidransky et al50
1q21.2	SYT11	0.02	1.44	Nalls et al73	Nalls et al73
1q32	RAB7L1	0.44	0.86	Satake et al62	Satake et al62
2q21.3	ACMSD	0.19	1.07	Nalls et al73	Nalls et al73
2q24.3	STK39	0.13	1.12	Nalls et al73	Nalls et al73
3q27	MCCC1/LAMP3	0.14	0.87	Nalls et al73	Nalls et al73
4p15	BST1	0.45	0.87	Satake et al62	Satake et al62
4p16	GAK	0.28	1.14	Pankratz et al66	Nalls et al73
4q21	SNCA	0.39	1.27	Kruger et al46	Simon-Sanchez et al; Satake et al62, 63
4q21.1	SCARB2	0.37	0.90	Do et al57	Do et al57
4q21.1	STBD1	0.36	0.91	IPDGC67	IPDGC67
6p21.3	HLA-DRB5	0.15	0.80	Hamza et al79	Hamza et al79
7p15	GPNMB	0.40	0.89	IPDGC67	IPDGC67
8p22	FGF20	0.27	0.88	Van der Walt et al80	IPDGC67
12q12	LRRK2	0.21	1.30	Skipper et al 81	Satake et al62
12q24	CCDC62/HIP1R	0.46	1.13	Nalls et al73	Nalls et al 73
16p11.2	STX1B	0.41	1.15	IPDGC67	IPDGC67
17p11.2	SREBF1	0.31	0.95	Do et al57	Do et al57
17q21.1	MAPT	0.22	0.80	Pastor et al82	Simon-Sanchez et al63

^*this does not imply that this gene is the biologically mediator of association, but is used for ease of annotation

^**based on p <5×10⁻⁸