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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Epilepsia. 2012 Nov 13;54(2):228–238. doi: 10.1111/epi.12008

Table 1.

Characteristics of patients selected for the study

Patient and classification Sex Age (years) Years since first unprovoked seizure AEDs at surgery MRI findings Pathology
Non-MTLE
1 M 23 11 cbz, phe Mass in L medial temporal lobe Anaplastic astrocytoma with oligodendroglial differentiation
2 F 33 14 cbz, pri Mass in L anterior temporal lobe Low grade astrocytoma
3 M 22 17 cbz, czp, vpa Mass in L temporal lobe Cellular astrocytoma
4 F 7 6 cbz, vpa -- Ganglioglioma
5 F 30 25 pri Enlarged L hippocampus with possible tumor in L temporal lobe Low grade astrocytoma
6 F 25 14 clo, pht R mesial temporal lobe cystic lesion Ganglioglioma
7 F 35 20 pb, pht Unremarkable Mild hippocampal gliosis and neuronal loss
8 M 39 18 pht R lateral ventricle enlargement; atrophy and increased signal of R Hippocampus Mild hippocampal gliosis
9 F 43 34 cbz XR, ltg, tpm Possible tumor in L temporal lobe Gliosis in white matter of cerebral cortex
10 F 50 42 lev Chiari I malformation Heterotopic neurons in molecular layer of cerebral cortex; gliosis in amygdala
MTLE
1 M 17 1 pht Atrophic R hemisphere Hippocampal sclerosis
2 M 37 31 cbz Mucus retention cyst in R temporal lobe Hippocampal sclerosis
3 M 37 -- none -- Hippocampal sclerosis
4 M 50 -- none L hippocampal atrophy Hippocampal sclerosis
5 M 18 <1 cbz, czp, pht Unremarkable Hippocampal sclerosis
6 F 27 20 cbz Infarct in R occipital lobe status post R occipital lobectomy; R occipital lesion, questionable cavernous hemangioma Hippocampal sclerosis
7 M 16 11 vpa R mesial temporal atrophy; T2 intensity changes in R anterior hippocampus and amygdala Hippocampal sclerosis
8 M 32 29 pht, pri L hippocampal atrophy Hippocampal sclerosis
9 M 25 16 dpa, pht, pri L hippocampal atrophy Hippocampal sclerosis
10 F 44 34 cbz, czp, vpa Hypo-intense abnormality in L anterior temporal tip; R hippocampal atrophy Hippocampal sclerosis
11 F 24 18 ace, cbz R hippocampal and R temporal neocortical atrophy Hippocampal sclerosis
12 M 26 23 pht L hippocampal atrophy Hippocampal sclerosis
13 F 52 27 pht, vpa R hippocampal atrophy Hippocampal sclerosis
14 F 18 7 cbz, ltg, pht Unremarkable Hippocampal sclerosis
15 M 22 -- none Infarct in R inferior temporal lobe Hippocampal sclerosis
16 F 22 8 pb, pht Bilateral hippocampal atrophy; diffuse hemisphere atrophy; L frontal lobe encephalomalacia Hippocampal sclerosis
17 F 14 9 cbz XR, ltg L mesial temporal sclerosis; increased signal on FLAIR sequence in L hippocampus Hippocampal sclerosis
18 F 54 43 ltg, pri R mesial temporal sclerosis; increased signal on FLAIR sequence in R hippocampus Hippocampal sclerosis
19 M 15 11 czp, pht, pri L hippocampal atrophy; signal abnormality in R frontal lobe Hippocampal sclerosis
Patient and classification Sex Age (years) Postmortem interval (hrs) Cause of death
Autopsy
1 M 33 6 Adenocarcinoma of lung with widespread metastases
2 M 52 3 Myocardial infract, coronary atherosclerosis
3 F 49 5 Ruptured berry aneurysm, R posterior inferior cerebellar artery
4 F 76 4 Peritonitis

Abbreviations: ace, acetazolamide; AEDs, antiepileptic drugs; cbz, carbamazepine; clo, cloracepate; czp, clonazepam; dpa, dipropylacetic acid; L, left; ltg, lamotrigine; MTLE, mesial temporal lobe epilepsy; pb, phenobarbital; pht, phenytoin; pri, primidone; R, right; tpm, topiramate; vpa, valproate; XR, extended release. (“—“ indicates data not available).

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