Table 1.
Prevalence of five polymorphisms in homocysteine metabolizing genes in 997 Caucasian and 692 African American participants of the CARDIA study.
| Genotype | Prevalence n (%) | |
|---|---|---|
| Caucasian | African American | |
| CBS 844ins68a | ||
| −/− b | 854 (85.7) | 409 (59.1) |
| −/+c | 135 (13.5) | 230 (33.2) |
| +/+d | 8 (0.8) | 53 (7.7) |
| MS 2756A>G | ||
| AA | 622 (62.4) | 378 (54.6) |
| AG | 327 (32.8) | 251 (36.3) |
| GG | 48 (4.8) | 63 (9.1) |
| MTRR 66A>Ga | ||
| AA | 278 (27.9) | 54 (7.8) |
| AG | 502 (50.4) | 282 (40.8) |
| GG | 217 (21.8) | 356 (51.5) |
| MTHFR 677C>Ta | ||
| CC | 452 (45.3) | 547 (79.1) |
| CT | 417 (41.8) | 136 (19.7) |
| TT | 128 (12.8) | 9 (1.3) |
| MTHFR 1298A>Ca | ||
| AA | 478 (47.9) | 472 (68.2) |
| AC | 403 (40.4) | 197 (28.5) |
| CC | 116 (11.6) | 23 (3.3) |
a
P<0.05 for Caucasians vs. African Americans
b
no 844ins68 present
c
heterozygous for 844ins68
d
homozygous for 844ins6