Table 2.
Overall geometric mean concentrations of folate and tHcy and tHcy by genotype in 997 Caucasians and 692 African American participants of the CARDIA study.
| Caucasian | African American | |||||
|---|---|---|---|---|---|---|
| y 0 (1985) | y 7 (1992) | y 15 (2000) | y 0 (1985) | y 7 (1992) | y 15 (2000) | |
| Folatea, nmol/L | 11.96(11.17–12.80) | 17.08b(16.31–17.87) | 34.07bc(32.04–36.22) | 7.93(7.36–7.58) | 10.71b(10.15–11.33) | 24.64bc (23.19–26.16) |
| tHcya, umol/L | ||||||
| 10.35(10.04–10.67) | 9.4b(9.20–9.61) | 8.22bc(7.96–8.48) | 10.67(10.30–11.06) | 10.17 (9.91–10.44) | 8.66bc(8.40–8.93) | |
| CBS 844ins68 | ||||||
| −/− | 9.83(9.60–10.06) | 9.30(9.09–9.51) | 8.51, 8.37–8.65) | 9.93( 9.63–10.23) | 9.95( 9.62–10.28) | 8.79( 8.56–9.03) |
| −/+ | 9.46(8.92–10.03) | 8.82(8.33–9.34) | 8.15( 7.82–8.50) | 9.75( 9.37–10.15) | 9.51( 9.11–9.94) | 8.57( 8.28–8.87) |
| +/+ | 9.86(7.77–12.50) | 8.66(6.87–10.93) | 8.09( 6.83–9.58) | 9.44( 8.69–10.26) | 9.48( 8.66–10.39) | 8.56( 7.97–9.19) |
| MS 2756A>G | ||||||
| AA | 9.74(9.48–10.00) | 9.25(9.01–9.50) | 8.42(8.26–8.58) | 10.07(9.76–10.39) | 10.02(9.68–10.36) | 8.86(8.62–9.10) |
| AG | 9.94(9.57–10.32) | 9.17(8.84–9.51) | 8.59(8.36–8.82) | 9.67(9.30–10.05) | 9.65(9.25–10.07) | 8.68(8.40–8.98) |
| GG | 9.29(8.43–10.24) | 9.33(8.49–10.26) | 8.18(7.63–8.76) | 9.06d(8.38–9.30) | 8.73e(8.01–9.51) | 7.84e(7.33–8.38) |
| MTRR 66A>G | ||||||
| AA | 9.97(9.58–10.38) | 9.30(8.95–9.67) | 8.48(8.24–8.72) | 9.54(8.72–10.44) | 9.83(8.93–10.82) | 8.40(7.79–9.06) |
| AG | 9.74(9.44–10.04) | 9.29(9.01–9.57) | 8.47(8.29–8.66) | 9.97(9.61–10.34) | 9.68(9.30–10.08) | 8.69(8.42–8.97) |
| GG | 9.62(9.20–10.07) | 9.00(8.61–9.41) | 8.41(8.15–8.69) | 9.76(9.45–10.08) | 9.82(9.48–10.17) | 8.75 (8.51–8.99) |
| MTHFR 677C>T | ||||||
| CC | 9.35(9.06–9.64) | 8.97(8.70–9.24) | 8.37(8.18–8.56) | 9.65(9.40–9.90) | 9.55(9.29–9.82) | 8.62(8.43–8.81) |
| CT | 9.65(9.35–9.97) | 9.04(8.76–9.33) | 8.39(8.19–8.59) | 10.42e(9.90–10.98) | 10.26d(9.70–10.85) | 8.98(8.59–9.40) |
| TT | 11.90f(11.24–12.59) | 10.85f(10.26–11.48) | 9.02e(8.65–9.40) | 12.64d(10.19–15.68) | 18.82f(14.93–23.74) | 9.64(8.00–11.62) |
| MTHFR 1298A>C | ||||||
| AA | 9.95(9.65–10.26) | 9.33(9.06–9.62) | 8.70(8.29–8.66) | 9.91(9.64–10.20) | 9.75(9.46–10.06) | 8.48(8.49–8.91) |
| AC | 9.55(9.23–9.87) | 9.04(8.75–9.34) | 8.66(8.20–8.60) | 9.56(9.16–9.98) | 9.68(9.24–10.15) | 8.40(8.35–8.99) |
| CC | 9.89(9.28–10.54) | 9.44(8.88–10.04) | 9.12(8.23–9.01) | 10.56(9.28–12.00) | 10.65(9.24–12.26) | 8.61(8.16–10.18) |
a
Concentrations are expressed as geometric mean (95%CI) adjusted for age, gender and smoking status
b
P <0.001 for differences compared to y 0
c
P <0.001 for differences compared to y 7
d
P<0.05 for 2756GG vs. AA, 677CT vs. CC and 677TT vs. CC
e
P<0.01 for 2756GG vs. AA, 677CT vs. CC and 677TT vs. CC
f
P<0.001 for 677TT vs. CC