. Author manuscript; available in PMC: 2013 Feb 21.

Published in final edited form as: Mol Genet Metab. 2009 Jun 6;98(1-2):181–186. doi: 10.1016/j.ymgme.2009.05.012

Table 3.

Polygenic influence of variants in the CBS, MS, MTRR and MTHFR genes on tHcy concentrations before (y 0, y 7) and after (y 15) folic acid fortification in 997 Caucasians and 692 African Americans in the CARDIA study.

	Variable	y 0, 1985	y 7, 1992	y 15, 2000	y 0 – 15	y 7 – 15
Caucasian	P-value for model^a	<.001	<.001	<.001	<.001	<.001
	R square for model	0.17	0.21	0.26	0.06	0.05
	P-value for F-test^b
	CBS 844ins68	0.61	0.37	0.19	0.91	0.98
	MS 2756A>G	0.44	0.84	0.33	0.71	0.43
	MTRR 66A>G	0.36	0.52	0.93	0.91	0.64
	MTHFR 677C>T	<.001	<.001	0.004	<.001	<.001
	MTHFR 1298A>C	0.06	0.1	0.29	0.38	0.64
African American	P-value for model^a	<.001	<.001	<.001	0.015	<.001
	R square for model	0.13	0.17	0.18	0.04	0.17
	P-value for F-test^b
	CBS 844ins68	0.48	0.22	0.39	0.95	0.35
	MS 2756A>G	0.03	0.01	0.007	0.73	0.88
	MTRR 66A>G	0.5	0.93	0.61	0.52	0.58
	MTHFR 677C>T	0.003	<.001	0.17	0.001	<.001
	MTHFR 1298A>C	0.34	0.3	0.69	0.82	0.75

Codominant model was contructed for the genetic variants

ANOVA was used to identify significant association between genetic variants and tHcy after adjusting for other genes.