Table 4.

Laryngeal preservation trials

Trial (year)	No. of patients (n)	Stage	Design (arms)	Result
VACSP, 1991	332	III & IV	Arm A: Surgery f/b CT	3 year overall survival (53 % vs 56 %) both arms. Larynx preservation in 66 %
		Laryngeal Ca	Arm B: CT f/b RT
EORTC, 1996	194	II,III,IV	Arm A: Surgery f/b CT	5 year overall survival equal in both arms
		Laryngeal Ca	Arm B: CT f/b RT	Larynx preservation 33 % at 5 year
RTOG (91-11) (2001)	547	III, IV	Arm A: Conc.CT + RT	5 year overall survival equal in 3 arms
		Laryngeal Ca	Arm B: CT f/b RT	Larynx preservation in Arm A: 70 %
			Arm C: RT only	Arm B: 88 %
				Arm C: 65 % (P: sig)

VACSP veterans administration cooperative study program, EORTC European organisation for research and treatment of cancer, RTOG radiation therapy oncology group