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. Author manuscript; available in PMC: 2013 Feb 21.
Published in final edited form as: Cell Stem Cell. 2011 Mar 4;8(3):267–280. doi: 10.1016/j.stem.2011.01.013

Figure 7. Effect of ROCK Inhibitor, Y-27632, on Patient-derived DA Neurons.

Figure 7

(A) Representations of neurodegeneration in H9-, HUF5- and G2019S-iPSC derived neurons when treated with neurotoxins, H2O2 and MG-132, and ROCK inhibitor Y-27632. Scale bar = 50 µm.

(B) Quantification of cells double positive for TH and CASP3. Data represent mean ± SEM (n = 2–3 wells per iPSC clone; average of 3 clones of HUF5 and two clones of G2019S).

(C) Quantification of TH-negative (TUJ+) neurons also positive for CASP3 after treatments as described above. Data represent mean ± SEM (n = 2 to 3 wells per clone).

See also Table S4 for cell counts.