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. Author manuscript; available in PMC: 2014 Jan 14.
Published in final edited form as: Cancer Cell. 2012 Dec 27;23(1):107–120. doi: 10.1016/j.ccr.2012.11.013

Figure 6. FTY720 represses development of CAC.

Figure 6

(A–D) Schematic overview of FTY720 administration during CAC induction, PBS or FTY720 (0.3 mg/kg) was administered by gavage 5 times per week from day 1 to day 140 (FTY720day 1–140) (A). Tumor number per mouse (B), tumor size (C), and tumor load (D) were analyzed on day 140.

(E–H) Schematic overview of FTY720 treatment during the late stage of CAC induction, PBS or FTY720 (0.3 mg/kg) was administered 5 times per week beginning one day after the last DSS cycle (day 51) to day 120 (FTY720day 51–120) (E). Tumor number per mouse (F), tumor size (G), and tumor load (H) were analyzed on day 140.

Data are means ± SEM, n=7–8, *p<0.05, **p<0.01