Table 1. Patients with Skull Base Involvement by Acinic Cell Carcinoma of Parotid Origin.
| Patient | Age at original diagnosis | Gender | Skull base disease at initial presentation? | Type of initial surgery | Grade | Extracapsular extension | Margins at initial excision | Initial adjuvant therapy | Time to first recurrence (years) | Time to development of skull base disease (years) | Location of skull base disease | Treatment of skull base disease | Cervical metastases? | Distant metastases? |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 18 | F | No | Total parotidectomy | 2 | No | Positive | None | 4 | 12 | Glenoid fossa, infratemporal fossa, Foramen ovale, Meckel's cave, cavernous sinus, sphenoid sinus, clivus, cerebellum | Extended parotidectomy, partial mandibulectomy, fibular free flap (FFF). External beam and stereotactic radiation. | − | + |
| 2 | 76 | M | No | Superficial parotidectomy | DNA | DNA | DNA | None | 64 | 10.1 | Masticator space, temporal fossa | External beam radiation | + | − |
| 3 | 23 | F | No | Superficial parotidectomy | 2 | No | Negative | None | DNA | 47.2 | Parapharyngeal space, petrous temporal bone | LTBR, partial mandibulectomy, FFF. Developed subsequent recurrence at petrous temporal bone and clivus. | − | + |
| 4 | 49 | M | No | Superficial parotidectomy with upper division facial nerve sacrifice | 1 | No | Negative | None | 0.8 | 14.3 | Stylomastoid foramen, EAC | Revision parotidectomy, LTBR, EAC resection, SCM flap. Developed extensive skull base recurrence with intracranial spread to MCF. | + | − |
| 5 | 79 | F | No | Total parotidectomy | 2 | Yes | Negative | Radiation | 2.6 | 4 | Stylomastoid foramen, jugular foramen | None | − | − |
| 6 | 55 | M | Yes | Total parotidectomy, upper division facial nerve sacrifice, modified radical neck dissection, mastoidectomy | 2 | Yes | Positive | Radiation | 0.9 | DNA | EAC, petrous temporal bone and mastoid, posterior cranial fossa | Subtotal TB resection, removal of sigmoid sinus and adjacent dura, trapezius flap, stereotactic radiation. | − | + |
| 7 | 61 | M | Yes | None | DNA | DNA | DNA | DNA | DNA | DNA | On original presentation - TMJ, parapharyngeal space, foramen ovale | None | + | + |
| 8 | 72 | M | No | Total parotidectomy, select neck dissection | 1 | No | Negative | None | 2.2 | 10.3 | Sphenoid sinus, cavernous sinus, clivus, parietal bone | Stereotactic radiation | − | − |
| 9 | 39 | F | No | Parotidectomy of unknown extent | DNA | DNA | DNA | None | 36.5 | 36.5 | Stylomastoid foramen | None | − | − |
| 10 | 48 | F | No | Total parotidectomy, select neck dissection, radial forearm free flap | 1 | No | Negative | None | 15.3 | 15.3 | Stylomastoid foramen | Stereotactic radiation | − | − |
DNA, data not available.