Table 2. Baseline characteristics of participating patients.
| Item | Total (n = 200) | United Kingdom (n = 50) | United States (n = 75) | France (n = 75) |
|---|---|---|---|---|
| Proportion female | 46% | 48% p = 0.751 |
49% p = 0.571 |
40% p = 0.414 |
| Age (mean) | 68 years | 72 years p = 0.048 |
61 years p = 0.000 |
71 years p = 0.047 |
| Patients who had an amputation of the affected limb | 9% | 8% p = 0.683 |
7% p = 0.418 |
11% p = 0.176 |
| Patients with planned amputation | 3% | 4% p = 0.720 |
1% p = 0.436 |
4% p = 0.678 |
| CLI diagnosis (year) | 2002 | 2001 p = 0.139 |
2005 p = 0.011 |
2001 p = 0.239 |
| Patients who had a surgery to restore blood flow | 42% | 38% p = 0.653 |
20% p = 0.001 |
65% p = 0.000 |
| Symptoms | ||||
| Pain when walking shorter distances | 66% | 67% p = 0.870 |
53% p = 0.052 |
79% p = 0.049 |
| Pain while resting | 67% | 74% p = 0.383 |
61% p = 0.387 |
69% p = 0.829 |
| Open wound/skin lesion at affected limb | 73% | 89% p = 0.020 |
71% p = 0.842 |
63% p = 0.128 |
| Inflammation | 67% | 65% p = 0.852 |
74% p = 0.244 |
60% p = 0.309 |
| Numbness of legs | 42% | 41% p = 0.924 |
33% p = 0.181 |
52% p = 0.154 |
| Comorbidities | ||||
| Hypertension | 71% | 70% p = 0.889 |
71% p = 0.956 |
72% p = 0.870 |
| Diabetes | 54% | 52% p = 0.849 |
55% p = 0.863 |
53% p = 0.980 |
| Heart failure | 23% | 18% p = 0.446 |
23% p = 0.953 |
27% p = 0.527 |
| Pulmonary diseases | 15% | 20% p = 0.339 |
13% p = 0.805 |
12% p = 0.593 |
| Renal diseases | 13% | 16% p = 0.514 |
12% p = 0.910 |
11% p = 0.677 |
| Anemia | 11% | 14% p = 0.554 |
11% p = 0.937 |
9% p = 0.689 |
| Cancera | 7% | 10% p = 0.393 |
8% p = 0.663 |
3% p = 0.214 |
| Previous treatment | ||||
| Bypass operation/replacement of blood vessels | 20% | 10% p = 0.101 |
12% p = 0.124 |
35% p = 0.011 |
| Mechanical dilation of blood vessels (e.g., balloon angioplasty) | 27% | 34% p = 0.328 |
11% p = 0.004 |
39% p = 0.062 |
| Other blood vessel surgeries | 13% | 12% p = 0.850 |
13% p = 0.941 |
13% p = 0.941 |
| Amputation of a leg or lower leg above the ankle | 8% | 10% p = 0.561 |
9% p = 0.618 |
4% p = 0.297 |
| Amputation of the foot or parts of the foot below ankle | 9% | 6% p = 0.561 |
3% p = 0.091 |
16% p = 0.072 |
| Infusion of drugs restoring the blood flow | 11% | 4% p = 0.157 |
11% p = 0.968 |
15% p = 0.338 |
| Oral drugs restoring the blood flow | 61% | 54% p = 0.368 |
49% p = 0.082 |
77% p = 0.011 |
| Pain medication | 76% | 76% p = 0.941 |
83% p = 0.207 |
68% p = 0.211 |
| Wound care, for example, wound dressing and/or débridement | 72% | 84% p = 0.083 |
72% — |
64% p = 0.199 |
Abbreviations: a, currently diagnosed or diagnosis within the last 5 years; CLI, critical limb ischemia.
Note: A p values tested at a 90% confidence interval for each country versus total (n = 200).