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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Pediatr Neurol. 2013 Mar;48(3):167–178. doi: 10.1016/j.pediatrneurol.2012.09.014

Table 1.

Specific liver histological findings in Alpers-Huttenlocher syndrome.

At least three of the following must be present: (Wilson disease has been ruled out)

  1. Bridging fibrosis or cirrhosis

  2. Bile ductular proliferation

  3. Collapse of liver cell plates

  4. Hepatocyte dropout or focal necrosis with or without portal inflammation

  5. Microvesicular steatosis

  6. Oncocytic change (mitochondrial proliferation associated with intensely eosinophilic cytoplasm in scattered hepatocytes and not affect by steatosis

  7. Regenerative nodules

  8. Parenchymal disease or disorganization of the normal lobular architecture

Adapted from [9]