Figure 1.
Representative example of surface (lead V1) and intracardiac electrograms (posterolateral left atrium, LA) at 12 min after atrial fibrillation (AF) initiation demonstrating early termination of AF by ranolazine. Note in the upper tracing (control) that AF is characterized by low voltage and high frequency. At the same time period, with ranolazine treatment, the arrhythmia became more organized, followed by conversion to sinus rhythm. (Reprinted from ref.24 with permission from John Wiley & Sons.).