Table 2.

Effects of ranolazine on various ion channel currents

Ion channel current	Preparation	Potency (IC50, μM)	Comments	References
Peak INa	Canine ventricular myocytes	294	Tonic block	Undrovinas et al.56
	KPQ murine cardiomyocytes	135		Fredj et al.57
	HEK293 cells	428		Rajamani et al.41
	HEK293 cells	285		Zygmunt et al.58
Late INa	Canine ventricular myocytes	5.9	Tonic block	Antzelevitch et al.53
	Canine ventricular myocytes KPQ	6.5		Undrovinas et al.56
	Murine cardiomyocytes	15		Fredj et al.57
	HEK293 cells	6.9		Wu et al.59
	Rabbit ventricular myocytes	16.5		Jia et al.60
IKr	Canine ventricular myocytes	11.5		Antzelevitch et al.53
	HEK293 cells	14.4		Wu et al.59
INCX	Canine ventricular myocytes	91		Antzelevitch et al.53
	tsA201 cells	1.7		Soliman et al.61
	Rabbit ventricular myocytes	>100		Gilead, unpublished data
ICa,L	Canine ventricular myocytes	296		Antzelevitch et al.53