Table 2.
Ion channel current | Preparation | Potency (IC50, μM) | Comments | References |
---|---|---|---|---|
Peak INa | Canine ventricular myocytes | 294 | Tonic block | Undrovinas et al.56 |
KPQ murine cardiomyocytes | 135 | Fredj et al.57 | ||
HEK293 cells | 428 | Rajamani et al.41 | ||
HEK293 cells | 285 | Zygmunt et al.58 | ||
Late INa | Canine ventricular myocytes | 5.9 | Tonic block | Antzelevitch et al.53 |
Canine ventricular myocytes KPQ | 6.5 | Undrovinas et al.56 | ||
Murine cardiomyocytes | 15 | Fredj et al.57 | ||
HEK293 cells | 6.9 | Wu et al.59 | ||
Rabbit ventricular myocytes | 16.5 | Jia et al.60 | ||
IKr | Canine ventricular myocytes | 11.5 | Antzelevitch et al.53 | |
HEK293 cells | 14.4 | Wu et al.59 | ||
INCX | Canine ventricular myocytes | 91 | Antzelevitch et al.53 | |
tsA201 cells | 1.7 | Soliman et al.61 | ||
Rabbit ventricular myocytes | >100 | Gilead, unpublished data | ||
ICa,L | Canine ventricular myocytes | 296 | Antzelevitch et al.53 |