Table 1.
Electrocardiographic and Echocardiographic Data
| Controls |
AdCx43 Animals |
|||||
|---|---|---|---|---|---|---|
| Variable | Pre-MI | Pre-GTx | Post-GTx | Pre-MI | Pre-GTx | Post-GTx |
| Electrocardiography | ||||||
| P-wave duration (ms) | 64 ±1 | 75 ±2 | 74 ±3 | 70 ±3 | 80 ±3 | 78 ± 5 |
| PR interval (ms) | 107 ± 4 | 115 ± 4 | 115 ± 4 | 118 ± 2 | 121 ± 4 | 124 ± 6 |
| QRS duration (ms) | 62 ±4 | 84 ±4 | 78 ±3 | 67 ±2 | 74 ±3 | 77 ± 2 |
| QTc interval (ms) | 410 ± 14 | 422 ± 14 | 411 ± 11 | 454 ± 12 | 429 ± 10 | 431 ± 7 |
| RR interval (ms) | 560 ± 30 | 422 ± 14 | 529 ± 30 | 628 ± 25 | 522 ± 29 | 544 ± 36 |
| Echocardiography | ||||||
| LVEF | 69 ±2 | 39 ±4 | 66 ±2 | 38 ± 2 | ||
| LV internal diameter-diastole | 3.8 ± 0.1 | 4.9 ± 0.2 | 3.4 ± 0.1 | 4.5 ± 0.1 | ||
| Septal width in diastole | 0.9 ± 0.1 | 0.6 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | ||
| LV posterior width in diastole | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | ||
Values are mean ± SD. The pre-MI study was performed immediately before the infarct procedure, the pre-GTx study was performed immediately the GTx procedure (post-MI week 4), and the post-GTx study was performed 1 week after GTx (post-MI week 5). Echocardiography was not performed at the pre-GTx time point. There were no significant differences comparing pre-GTx with post-GTx within groups or comparing between the control and AdCx43 groups.
GTx = gene transfer; LV = left ventricular; LVEF = left ventricular ejection fraction; MI = myocardial infarction; QTc = Bazett’s corrected QT interval.