FIG 4.
AHR in WT bone marrow–derived MC–reconstituted infected mice. A, Engraftment of MCs (arrows) verified by means of immunohistochemistry in lung tissue 1 month after injection. B, Quantification of engraftment. C, AHR to methacholine challenge was measured by using the Flexivent system. Mean percentage over baseline for highest methacholine dose is shown in parentheses. **P < .01, #P < .01, and ^P < 0.05, 3 independent experiments per graph. D, TNF-α in BAL fluid 12 hours after infection. *P < .05 versus WT Mycoplasma pneumoniae group, n ≥ 12 mice per group. Mp, Mycoplasma pneumoniae.