Fig. 1.

Scheme of CML hematopoietic stem cell signaling pathways in which predicted targets of microRNAs associated with CML are involved. A. microRNAs identified by Machova Polakova et al. [53•]: miR-103, miR-150 and miR-144 were found to be decreased in peripheral blood cells of blast crisis, while other illustrated micoRNAs were increased; B. microRNAs identified by Rokah et al. [58]: all four illustrated microRNAs were found to be decreased in the K562 cell line. MAPK pathway is shown in blue, Transforming growth factor beta signaling pathway in purple and cell cycle with p53 pathway in green. Note: the scheme is modified according to the hsa05220 of the KEGG database (Kanehisa M, Goto S, Furumichi M, et al.: KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 2010, 38:D355-D360.)