Table 3. Novel resistance conferring mutations derived from the dataset (NRTI).

Mutation	3TC	ABC	AZT	D4T	DDC	DDI	TDF	FTC	Average Log FC
I63V*	0.22	n/a	1.07	0.53	n/a	0.52	0.01	0.36	0.45
I202M*	0.23	n/a	0.73	0.68	0.51	0.57	0.45	0.39	0.51
R206M	0.90	0.42	0.54	0.01	0.15	0.17	0.24	0.92	0.42
T216M	0.88	0.51	0.66	0.12	0.20	0.27	0.38	0.94	0.50
E298K*	0.33	0.43	0.44	0.38	0.65	0.32	n/a	n/a	0.43
Average Susceptibility	0.51	0.45	0.69	0.34	0.38	0.37	0.27	0.65	-

The value in the different drug columns indicates the average Log FC in the presence of this mutation, when not available in the dataset the value is denoted ‘n/a’. Mutations indicated with an asterisk were incompletely tested on all drugs in the dataset. Like the NNRTI resistance mutations, each mutation displays a different resistance profile over all drugs. AZT is seen to be the most susceptible (average Log FC 0.69) and TDF the least susceptible (average Log FC 0.27).