Table 6. Description of the dataset used in the current study (Obtained from Virco).
Target | Amino acids | Binding Site | Drug Class | Drugs | Mutant Sequences | Data points | Mean number of mutations |
Reverse Transcriptase | 400* | Orthosteric | NRTI | 8 | 10,501 | 72,727 | 22 (±9) |
Reverse Transcriptase | 400* | Allosteric | NNRTI | 4 | 10,723 | 35,249 | 22 (±9) |
Protease | 99 | Orthosteric | PI | 9 | 27,081 | 180,162 | 10 (±6) |
For Reverse Transcriptase only the first 400 amino acids were sequenced. The total size of the dataset is unlike any other dataset used in PCM. The number of mutations shown in the last column is the average per sequence and standard deviation when compared to HXB2.