Figure 2. Representative Manhattan plots.

The dashed horizontal line corresponds to a p-value of 10⁻⁸. (a–f) The −log₁₀ of the p-value of the logistic regression is shown for representative examples for different mean effect sizes of causative mutations (λ). The plots are separated into four classes of mutations: common neutral and causative variants, which could be typed in a GWAS, and rare neutral and causative variants which would only be directly typed by resequencing.