Table 1. Serotype specificity and virus selective of the hit compounds in the 4-(1-aminoethyl)-N-methylthiazol-2-amine cluster.

Specificity					EC50 (µM)/SI
(Serotype)				Compound	CC50 (µM)	DENV1	DENV2	DENV3	DENV4
1	2	3	4	CND1203	>100	1.7/>59	4.1/>24	2.3/>43	5.0/>20
1	2	3	4	CND1201	>100	0.9/>111	7.6/>13	2.6/>38	5.0/>20
1	2	3	4	CND1243	>100	4.1/>24	6.2/>16	1.0/>100	7.2/>14
1	2	3		CND1081	>100	1.5/>66	2.1/>48	3.1/>32	12/8.3
1	2			CND1043	43	4.1/10	3.1/14	5.7/7.5	6.9/6.2
1		3		CND1244	21	1.7/12	2.9/7.2	1.6/13	4.4/4.8
1				CND0975	44	1.0/44	5.5/8	>50/<1.0	>50/<1.0
	2			CND1057	23	3.3/7.0	1.0/23	2.9/7.9	10/2.3
			4	CND0968	29	>25/<1.2	6.4/4.6	6.2/4.7	1.1/26
				CND1020	25	3.9/6.4	13/1.9	3.4/7.3	19/<1.3
				CND1172	15	7.3/2.1	10.4/1.4	4.8/3.1	7.5/2.0

SI is determined by the formula: CC₅₀/EC₅₀.