Table 2. Case-control association study of 404 Spanish CMI patients and 519 sex-matched controls.
| Gene | Control Genotypes N (%) | All CMI Genotypes N (%) | Classical CMI Genotypes N (%) | |||||||||
| SNP (P<0.01) | 11 | 12 | 22 | 11 | 12 | 22 | P-val | 11 | 12 | 22 | P-val | |
| ALDH1A2 | rs2899611 | 110 (21) | 264 (51) | 145 (28) | NS | 59 (32) | 90 (48) | 37 (20) | 0.00201 * | |||
| rs6493979 | 78 (15) | 273 (53) | 168 (32) | 84 (21) | 207 (51) | 113 (28) | 0.02436 | 46 (25) | 95 (51) | 45 (24) | 0.00209 * | |
| rs2067062 | 148 (29) | 258(50) | 105 (21) | NS | 35 (20) | 93 (52) | 51 (28) | 0.00425 | ||||
| BMPR1A | rs12415784 | 5 (1) | 135 (26) | 379 (73) | 5 (1) | 76 (19) | 323 (80) | 0.02744 | 2 (1) | 29 (16) | 155 (83) | 0.00704 |
| CDX1 | rs887343 | 85 (16) | 252 (49) | 180 (35) | 43 (11) | 187 (46) | 174 (43) | 0.00181 | 16 (9) | 82 (44) | 88 (47) | 0.00044 * |
| rs2282809 | 71 (14) | 240 (46) | 206 (40) | 37 (9) | 174 (43) | 193 (48) | 0.00489 | 15 (8) | 76 (41) | 95 (51) | 0.00308 | |
| FLT1 | rs17086609 | 242 (47) | 222 (43) | 50 (10) | 149 (37) | 196 (49) | 55 (14) | 0.00183 | 67 (37) | 83 (45) | 33 (18) | 0.00137 * |
| rs9554320 | 104 (20) | 261 (50) | 153 (30) | NS | 25 (14) | 88 (47) | 73 (39) | 0.00575 | ||||
| MSGN1 | rs11689375 | 117 (23) | 245 (47) | 156 (30) | 60 (15) | 203 (51) | 137 (34) | 0.01225 | 21 (11) | 98 (53) | 64 (36) | 0.00810 |
| RARG | rs1554753 | 310 (60) | 182 (35) | 27 (5) | 272 (67) | 121 (30) | 11 (3) | 0.00732 | 146 (79) | 36 (19) | 4 (2) | 0.01752 |
| rs6580936 | 358 (69) | 146 (28) | 15 (3) | 310 (77) | 87 (21) | 7 (2) | 0.00767 | NS | ||||
| RDH10 | rs16938610 | 305 (59) | 178 (34) | 36 (7) | 262 (64) | 126 (31) | 16 (4) | 0.02209 | 127 (68) | 53 (29) | 6 (3) | 0.00903 |
An additional study analyzed 186 classical CMI patients and the same control population. Only markers with P-value<0.01 (Cochran-Armitage trend test) are shown.
*
Significant associations after applying 10% FDR.