Table 1. Spearman rank correlations (RT qPCR data vs. metabolite data)^a, in the expanded patient cohort, of genes identified by microarray screening.

	6-TGN			meTIMP			Ratio meTIMP/6-TGN
Gene	Rs	P	Arrayb	Rs	P	Arrayb	Rs	P	Arrayb
CD1D	0.27	0.05		−0.26	0.06	N	−0.33	0.02	N
CTSS	0.16	0.26		−0.39	0.003		−0.38	0.004	N
DEF8	0.32	0.02	P	−0.17	0.24		−0.27	0.05
FAM156A	0.18	0.18		−0.33	0.01	N	−0.34	0.01	N
GNB4	0.17	0.22		−0.33	0.01	N	−0.37	0.006	N
HVCN1	0.32	0.02	P	−0.09	0.51		−0.20	0.16	N
LAP3	0.24	0.08		−0.22	0.10		−0.28	0.04	N
PLCB2	0.19	0.17	P	−0.37	0.006		−0.37	0.006	N
TUSC2	0.41	0.002		−0.16	0.24	N	−0.31	0.02	N

^aGenes that showed a significant correlation (P<0.05) between relative gene expression levels (RT qPCR data) and the concentration of 6-TGN, meTIMP or the meTIMP/6-TGN concentration ratio in the expanded patient cohort (n = 54).

^bSignificant (P<0.001) positive (P) or negative (N) correlations observed in the microarray data of the explorative patient cohort (n = 21) are indicated.