Table 3. Spearman rank correlations (RT qPCR data vs. metabolite data)^a, in the expanded patient cohort, of purine/thiopurine related genes.^b .

	6-TGN		meTIMP		Ratio meTIMP/6-TGN
Gene	Rs	P	Rs	P	Rs	P
ENTPD1	−0.10	0.49	−0.27	0.05	−0.21	0.12
HPRT1	−0.28	0.04	0.06	0.68	0.13	0.35
IMPDH2	−0.11	0.45	0.29	0.03	0.30	0.03
MGST2	0.20	0.15	−0.41	0.002	−0.43	0.001
NME6	0.24	0.08	−0.27	0.05	−0.35	0.01
NT5E	−0.09	0.51	0.42	0.002	0.42	0.002
RAC1	0.27	0.04	−0.24	0.08	−0.37	0.006
SLC29A2	0.02	0.89	0.34	0.01	0.29	0.03
TPMT	−0.12	0.38	−0.45	<0.001	−0.34	0.01

^aGenes that showed a significant correlation (P<0.05) between relative gene expression levels (RT qPCR data) and the concentration of 6-TGN, meTIMP or the meTIMP/6-TGN concentration ratio in the expanded patient cohort (n = 54).

^bNone of the genes selected by means of their potential relationship with the mechanism, metabolism or transport of purines/thiopurines fulfilled the established significance level (P<0.001) in the microarray data.