Table 7. A multiple linear regression model for the concentration of 6-TGN.a .
Parameter | Estimate | 95% CI | P | |
Intercept | 0.08 | −0.16–0.31 | 0.52 | |
TUSC2 | −0.27 | −0.46–−0.07 | 0.008 | |
Glucocorticosteroids | Yes | −0.22 | −0.41–−0.04 | 0.02 |
5-ASAxGlucocorticosteroids | Yes | −0.11 | −0.25–0.03 | 0.14 |
The regression model is based on the expanded patient cohort (n = 54), using the natural logarithm of the 6-TGN concentration as dependent variable and the gene expression level (dCT value) of TUSC2, and glucocorticosteroid and 5-ASA therapy as independent variables. A higher dCT value is associated with a lower gene expression level. R2 = 0.27, P = 0.001.