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. 2013 Feb 21;8(2):e57708. doi: 10.1371/journal.pone.0057708

Figure 5. Anti-tumor activity of α-tomatine against orthotopic PC-3 cell tumors.

Figure 5

Luciferase expressing PC-3 cell orthotopic tumors established in male SCID mice (n  =  6 per treatment group) for 5 days were treated thrice weekly for 2 weeks with vehicle or α-tomatine (10 mg/kg). (A) Bioluminescence intensities emitted from PC-3 cell orthotopic tumors for each treatment group after 14 days of treatment. (B) Bioluminescent images at the end of the experiment of SCID mice carrying orthotopic tumors of luciferase expressing PC-3-luc cells. The upper row shows the vehicle control group, whereas the bottom row shows the α-tomatine (10 mg/kg) treatment group. (C) Graph of mean body weight for each treatment group versus the number of days after initial injection of PC-3 cells. Each bar or point represents the mean ± SEM of data (n = 6).* P<0.05, ** P<0.01, *** P<0.001 vs vehicle control.