Table 1. Reasons for not switching when first met immunological/clinical criteria for switch in patients receiving and not receiving CD4 monitoring.
| CD4 monitoring (LCM) | No CD4 monitoring (CDM) | |
| Total met clinical (WHO 4 event) or immunological (confirmed CD4<100 cells/mm3) criteria for switch and either switched >8 weeks later or did not switch | 132 (100%) | |
| Total met clinical criteria (WHO 4 event) for switch and either switched >8 weeks later or did not switch | 100 (100%) | |
| Reason for not initially switching patient reported (details below)* | 42 (32%) | 44 (44%) |
| No reason reported but switched within 6 months | 56 (42%) | 33 (33%) |
| Reason not reported, not switched within 6 months | 34 (26%) | 23 (23%) |
| Switched after 6 months | 27 | 21 |
| Died or last seen alive and not switched | 7 | 2 |
| Reason for not switching when first met criteria (% of those reporting a reason) | 42 (100%) | 44 (100%) |
| Patient judged to be doing well | 30 (71%) | 20 (45%) |
| CD4>200 | 19 | N/A |
| CD4 100-200 or <100 but still increasing | 9 | N/A |
| only been on ART for ∼1 year | 0 | 3 |
| clinical judgement that event not related to ART failure ** | 2 | 12 |
| client felt well and did not want to switch | 0 | 5 |
| On TB treatment with rifampicin | 10 (24%) | 14 (32%) |
| Poor adherer/defaulter | 1 (2%) | 4 (9%) |
| Too ill to switch | 0 (0%) | 4 (9%) |
| Oversight: should have switched | 1 (2%) | 2 (5%) |
*
based on a retrospective request for reasons why patients had not switched within 8 weeks of first meeting protocol switch criteria.
**
eg only presumptive diagnosis, responded to treatment for the clinical event, event judged related to recent period off ART, patient being monitored and doing well.