Table 1. Effect of SC-1 on the Tumor Take Rate of the Seven Colon Tumor Lines of the NCI60 Panel*.
Number of Cells Inoculated | ||||||
Cell Line | 100 | 1000 | 10000 | |||
Control | SC-1 | Control | SC-1 | Control | SC-1 | |
COLO 205 | 0/5 | 0/5 | 1/4 | 1/5 | 1/5 | 4/5 |
HCC-2998 | 0/5 | 0/5 | 0/5 | 0/5 | 2/5 | 2/5 |
HCT-15 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
HCT-116 | 1/5 | 0/5 | 3/5 | 2/5 | 3/5 | 5/5 |
HT29 | 0/5 | 2/5 | 0/5 | 3/5@ | 3/5 | 5/5 |
KM12 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 1/5 |
SW-620 | 0/5 | 0/5 | 1/5 | 0/5 | 1/5 | 2/5 |
TOTAL | 1/35 | 2/35 | 5/34 | 6/35 | 10/35 & | 19/35 |
Female NOD.SCID mice were inoculated s.c. with bulk population colon cell lines treated for 5 days as indicated with control media or media containing 0.1 µM SC-1.
@Significant difference between control and SC-1 treated groups in the HT29 colon tumor line, 0.0375<p<0.05.
Significant difference between control (10/35) and SC-1 (19/35) treated group for 7 colon tumor lines, p = 0.04.