Table 2. Calculated Time to 1000 mg Tumor Volume in 5 Colon Lines Forming Tumors*.
Day# | ||
Cell Line | Control | SC-1 |
COLO 205 | 513 | 101 |
HCC-2998 | 184 | 139 |
HCT-116 | 48 | 45 |
HT29 | 185 | 32 |
SW-620 | 126 | 98 |
NOD.SCID mice injected s.c. with treated colon tumor lines at 10,000 cells/inoculum. Linear curves were fitted to population averages plotted for time (up to 120 days) vs. calculated mean tumor size (range of r: 0.73–0.90). Because mice injected with KM12 treated cells formed only one tumor in SC-1 conditions and no tumors under control conditions, this result was excluded from the analysis. Colon tumor lines were treated with 0.1 µM SC-1 or control media five days prior to inoculation.
Mean day±S.E. was 211±79 for control vs. 83±19 for SC-1 treated (n = 5, p = 0.16, Student’s paired t test).