Table 3. Effect of SC-1 on In Vitro Kinase Inhibition in Selected Kinases*.
| Protein Kinase | IC50 (µM) |
| Abl1 | 0.005 |
| Akt1 | – |
| PIM1 | – |
| PKA | – |
| PKC | – |
| p70S6K | 1.4 |
| PLK2 | 2.2 |
| RSK1 | 0.5 |
| RSK2 | 2.5 |
| RSK3 | 3.3 |
| RSK4 | 10.0 |
*
SC-1 was evaluated for in vitro kinase inhibition utilizing a miniaturized 33P-based screening assay [41]. The maximum concentration tested was 10 µM. IC50 (inhibitory concentration of 50% of the control (DMSO) treatment) was calculated from a 3-fold serial dilution (n = 2). Dashed lines indicate no effect at or below the maximum concentration tested.