Table 2. CD14 monocyte genes induced by viral infection.
| HCV | |||||
| Symbol | GenBank | Control | HCV | FCa | GO Categoriesb |
| AREG | NM_001657 | 22 (109) | 526 (5) | 24.4 | cell-cell signaling |
| NCOA7 | W27126 | 9 (31) | 126 (2) | 13.5 | regulation of transcription, DNA-dependent |
| IL1A | NM_000575 | 11 (11) | 92 (5) | 8.8 | inflammatory response; anti-apoptosis |
| ANKDD1B | N81013 | 17 (38) | 141 (1) | 8.5 | signal transduction |
| EIF1AX | N73881 | 13 (34) | 115 (2) | 8.5 | translation; gene expression |
| CD83 | NM_004233 | 76 (4) | 544 (4) | 7.1 | immune response; signal transduction |
| IRF1 | AB209624 | 78 (25) | 553 (2) | 7.1 | transcription, DNA-dependent; I-kB kinase/NF-kB cascade |
| EGR3 | NM_004430 | 62 (20) | 356 (3) | 5.8 | cell-cell signaling; cell migration involved in sprouting angiogenesis |
| ME2 | NM_002396 | 180 (20) | 921 (2) | 5.1 | oxidation-reduction process |
| ATF3 | NM_004024 | 433 (3) | 2009 (3) | 4.6 | gluconeogenesis; regulation of transcription, DNA-dependent |
| PROS1 | NM_000313 | 48 (15) | 204 (2) | 4.3 | proteolysis |
| GPR183 | NM_004951 | 1052 (5) | 4337 (4) | 4.1 | immune response; G-protein coupled receptor signaling pathway |
| RASGEF1B | NM_152545 | 31 (13) | 127 (3) | 4.1 | signal transduction |
| APOL2 | NM_030882 | 33 (13) | 129 (2) | 3.9 | lipid metabolic process; lipid transport |
| PNPLA2 | X56789 | 140 (4) | 521 (2) | 3.7 | lipid metabolic process; lipid catabolic process |
| HIVUD | |||||
| Symbol | GenBank | Control | HIVUD | FC | GO Categories |
| TET2 | AK027819 | 1333 (3) | 2690 (1) | 2 | myeloid cell differentiation |
| CCL5 | NM_002985 | 420 (2) | 831 (2) | 2 | chemotaxis; chronic inflammatory response |
| GZMA | NM_006144 | 192 (2) | 373 (2) | 1.9 | immune response; apoptotic process; proteolysis |
| IL32 | NM_004221 | 259 (2) | 499 (1) | 1.9 | immune response; cell adhesion |
| CST7 | NM_003650 | 111 (2) | 213 (2) | 1.9 | immune response |
| GZMK | NM_002104 | 65 (2) | 122 (1) | 1.9 | proteolysis |
| LGALS3BP | NM_005567 | 602 (2) | 1082 (1) | 1.8 | defense response; cell adhesion |
| MORF4L2 | NM_012286 | 282 (2) | 503 (2) | 1.8 | regulation of cell growth; DNA repair |
| KLRD1 | NM_002262 | 71 (2) | 126 (2) | 1.8 | regulation of immune response |
| PRF1 | NM_005041 | 60 (2) | 106 (2) | 1.8 | immune response to tumor cell; apoptotic process |
| C2 | NM_000063 | 371 (2) | 613 (1) | 1.7 | innate immune response; proteolysis; complement activation |
| OTP | AI300650 | 171 (2) | 279 (2) | 1.6 | positive regulation of neuroblast proliferation; nervous system development |
| KLF5 | CB306177 | 197 (2) | 318 (2) | 1.6 | angiogenesis; regulation of transcription, DNA-dependent |
| CRIPAK | NM_175918 | 270 (2) | 430 (2) | 1.6 | negative regulation of protein kinase activity; ER-nucleus signaling pathway |
| MYC | NM_002467 | 562 (2) | 892 (2) | 1.6 | MAPK cascade; B cell apoptosis; release of cytochrome c from mitochondria |
| HIV | |||||
| Symbol | GenBank | Control | HIV | FC | GO Categories |
| IFI27 | T47364 | 26 (2) | 2974 (4) | 116 | type I interferon-mediated signaling pathway; induction of apoptosis by extracellular signals |
| SIGLEC1 | NM_023068 | 26 (2) | 430 (2) | 16.6 | inflammatory response; cell adhesion; endocytosis |
| DEFB1 | NM_005218 | 8 (21) | 123 (3) | 14.7 | chemotaxis; immune response |
| ETV7 | NM_016135 | 28 (9) | 383 (2) | 13.8 | regulation of transcription |
| SERPING1 | NM_000062 | 237 (2) | 2006 (2) | 8.5 | inflammatory/immune response; complement activation |
| GBP1P1 | CA309689 | 134 (2) | 984 (2) | 7.3 | |
| IFIT1 | NM_001548 | 646 (1) | 4714 (2) | 7.3 | DNA replication, recombination and repair |
| RSAD2 | NM_080657 | 201 (1) | 1408 (2) | 7 | immune response; defense response to virus |
| LGALS3BP | NM_005567 | 602 (2) | 4181 (2) | 6.9 | defense response; cell adhesion |
| CXCL11 | NM_005409 | 54 (2) | 349 (2) | 6.4 | chemotaxis; inflammatory/immune response |
| IFI44L | NM_006820 | 1169 (1) | 7396 (2) | 6.3 | immune response |
| KLHDC7B | AA854620 | 387 (1) | 2334 (2) | 6 | protein binding |
| CFB | NM_001710 | 33 (3) | 196 (2) | 5.9 | innate immune response; complement activation; proteolysis |
| ATP10A | BC052251 | 24 (3) | 139 (2) | 5.8 | phospholipid transport; regulation of cell shape |
| CCL8 | NM_005623 | 57 (2) | 307 (2) | 5.4 | monocyte chemotaxis; angiogenesis |
a
Fold change based on mean probe intensity.
b
Geng002e Ontology.