Table 4. Incidence of anaphylaxis or death in general population treated with benzathine penicillin: individual and pooled results, 1954–2012.

Individual studies orpooled results	No. ofpatients	Death		Anaphylaxis
		Events	Absolute risk (95% CI)	Events	Absolute risk % (95% CI)
Shafer 1954 [87]	70,037	2	0.003 (0.001–0.009)	0	0 (0–0.004)
Smith 1956 [88]	7,109	0	0 (0–0.042)	0	0 (0–0.042)
Willcox 1957 [89]	895	0	0 (0–0.334)	0	0 (0–0.334)
Hsu 1958 [90]	32	1	3.125 (0.156–14.460)	1	3.125 (0.156–14.460)
International rheumatic fevergroup 1991 [92]	1,790	1	0.126 (0.006–0.623)	4	0.223 (0.071–0.538)
Napoli 2000 [94]	9,203	0	0 (0–0,032)	2	0.022 (0.004–0.072)
Apter 2004 [95]	2,017,957	0	0 (0–0,001)	47*	0.001 (0,002–0,003)
Li 2012 [99]	1,094	0‡	0 (0–0.274)	0‡	0 (0–0.274)
Pooled result	2,108,117	4	0 (0–0); I2 = 0%	54	0.002 (0–0.003); I2 = 12%

Notes:

^*16 patients had anaphylaxis after the first prescription of penicillin and 32 had anaphylaxis after the second prescription of penicillin. One patient had anaphylaxis in both prescriptions. Total patients that experienced anaphylaxis in this study = 47.

^‡There were reported 16 events of Jarisch-Herxheimer reaction, which were not considered adverse drug reaction in present review.