Figure 6. Gene expression of pro-inflammatory cytokines related to the IL-12/12/15LO axis.

A) mRNA expression of IL-12Rβ2, B) IL-12Rβ1, C) IL-12p35, D) IL-12p40, E) STAT4, F) IFN-γ, G) TNF-α, and H) IL-1β in 4, 8, and 12 week old NOD and NOD-Alox15^null mice islets. All samples were run in triplicate with an (n = 6). Data are expressed as fold reduction compared to their aged matched control (NOD). *p<0.05 and ^#p<0.005 for NOD vs. NOD-Alox15^null at the same age. Filled bars represent NOD and open bars represent NOD-Alox15^null samples.