Table 3. Combined study of replication and first-stage GWAS samples.
| Replication study (902 cases, 1091 controls) | First-stage GWAS (746 cases, 1599 controls) | |||||||||||
| MAF | MAF | Combined analysis | ||||||||||
| SNP | Alleles a | Case | Control | P value | OR | Case | Control | P value | OR | P combined b | OR (95% CI) | I 2 (%) |
| rs2235359 | C/A | 0.110 | 0.099 | 0.280 | 1.12 | 0.099 | 0.0757 | 0.006581 | 1.345 | 0.6773 | 1.22 (1.05–1.41) | 32.6 |
| rs2185955 | G/A | 0.111 | 0.100 | 0.238 | 1.13 | 0.099 | 0.0754 | 0.005839 | 1.351 | 0.6221 | 1.23 (1.06–1.42) | 24.9 |
| rs12214383 | G/A | 0.450 | 0.417 | 0.036 | 1.14 | 0.469 | 0.426 | 0.005327 | 1.192 | 0.1721 | 1.17 (1.07–1.28) | 0 |
| rs12000 | G/A | 0.366 | 0.423 | 2.50E-04 | 0.79 | 0.363 | 0.406 | 0.004405 | 0.8316 | 0.0019 | 0.81 (0.74–0.89) | 0 |
| rs1150724 | G/A | 0.438 | 0.401 | 0.019 | 1.16 | 0.454 | 0.407 | 0.002783 | 1.208 | 0.1061 | 1.19 (1.09–1.30) | 0 |
| rs1150722 | G/A | 0.039 | 0.068 | 4.28E-05 | 0.55 | 0.0389 | 0.0559 | 0.0131 | 0.6825 | 3.00E-04 | 0.61 (0.49–0.75) | 5.3 |
| rs3800324 | A/G | 0.244 | 0.275 | 0.024 | 0.85 | 0.244 | 0.301 | 5.67E-05 | 0.75 | 0.0998 | 0.80 (0.72–0.88) | 30.0 |
| rs1997660 | A/G | 0.443 | 0.406 | 0.02 | 1.16 | 0.458 | 0.408 | 0.001234 | 1.226 | 0.1105 | 1.19 (1.09–1.31) | 0 |
a
Minor allele/major allele.
b
Significant P combined values (<0.00625, Bonferroni corrected α) are in bold.
MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.
I 2, Heterogeneity tests for Q statistics. As all of the I2 less than 50% (P>0.05), the fixed-effect (Mantel-Haenszel) model was used to combine the results from the two different cohorts.