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. 2013 Feb 21;8(2):e56924. doi: 10.1371/journal.pone.0056924

Figure 1. Survival of ToI-β pancreatic islet grafts in allogenic SJL- mice.

Figure 1

500 ToI-β islets were transplanted under the kidney capsule of allogeneic SJL mice. Rejection/graft survival was determined by tail blood glucose measurements. Graft rejection was defined as consecutive measurements of glycemia >200 mg/dl. (A) Untreated control mice (diamonds, n = 10); mice that were exposed to Dox 24 hours after transplantation (triangles, n = 9); and mice that were exposed to Bortezomib 24 hours after transplantation (circles, n = 8). Statistical analysis was done by Kaplan-Meier estimation and comparison of survival curves by the MedCalc logrank test. p = 0.004 Dox vs control, p = 0.001 BZB vs control. (B) Blood glucose of ToI-β islet grafts in untreated SJL control mice (black diamonds); mice exposed to Dox (triangles) and mice treated with Bortezomib (BZB, squares). Blood glucose areas under the curve (AUC) were smaller in treated vs untreated recipient mice: Dox vs. Control p = 0.025, BZB vs Control p = 0.01.