Table 5. Multi-variate general linear modeling of white-matter structural integrity, age and CBF: Significance of fit obtained from multi-variate general linear model, where each white matter microstructural parameter (i.e. FA, AD or RD) is modeled a function of CBF and age with the remaining parameters as covariates.

Structure	Parameter	Age	CBF
Genu	FA	p<0.01*	p = 0.05*
	AD	p<0.01*	p<0.01*
	RD	p<0.01*	p = 0.18
Body	FA	p = 0.35	p = 0.19
	AD	p = 0.52	p = 0.12
	RD	p = 0.04*	p = 0.79
Splenium	FA	p = 0.28	p = 0.21
	AD	p<0.01*	p = 0.01*
	RD	p = 0.20	p = 0.69

For example, the model for FA used AD and RD as covariates. The asterisk indicates statistical significance.