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. 2013 Feb 21;8(2):e56774. doi: 10.1371/journal.pone.0056774

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© 2013 Luo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Representative western blot for Skp2 protein (A) and agarose gel electrophoresis for RT-PCR products of p27 mRNA (B) in pulmonary arteries from control and HPH rats. Beta-actin was used as control. Summarized data are shown in the bottom respectively. Hypoxia significantly increased the Skp2 protein and mRNA level in pulmonary arteries from HPH rats, tanshinone IIA significantly reversed the effects of hypoxia on the expression of Skp2 (*P<0.05 vs nomoxia group, # P<0.05 vs hypoxia group, mean ± SEM, n = 3).